Abstract : Periodontitis is an inflammatory condition associated with bacterial overgrowth, and Gram-negative bacteria within the periodontal pockets have been shown to raise inflammatory markers. The NLRP3inflammasome is a vital elements of the innate immune system that activates and secretes pro-inflammatory cytokines in response to microbial (viral, bacterial. etc.) infections. Chronic inflammation brought on by host immunological responses is a common feature of periodontitis. The purpose of this review is to outline the function of the NLRP3 inflammasome in periodontal disease.