Abstract : Background
Sulfotransferase enzyme SULT1A1 responsible for sulfation of active tamoxifen metabolites and formation of inactive ingredients that losing their pharmacological activity.
The objective of this study is to identify SULT1A1 genetic polymorphisms in Iraqi breast cancer women and their effects on tamoxifen treatment response.
Patients and methods venous blood taken from each participated women used for assessment of genotyping for both SNP of SULT1A1 gene rs6839 and rs9282861
Results indicated that for rs6839, the wild type TT is the predominant genotype compared to mutant TC and CC type, however for rs9282861 the homozygous mutant TT is the predominant genotype in comparison to the mutant CT and wild type CC. Among the several genetic variations of the SULT1A1 gene, the results showed a high incidence of joint pain with a low recurrence rate.
Conclusion in this cross-sectional study, we observed that in Iraqi women with breast cancer, the wild type of rs6839 was more common than the mutant version, and vice versa for rs9282861. However, these findings had only a small impact on side effects and recurrence among the patients. Large sample size is necessary to evaluate the true significance of the current findings and their potential impact on the prognoses of breast cancer patients.