Abstract : The individual and combined effect of oxymatrine insecticide and the entomopathogenic fungi, Beauveria bassiana and Isaria fumosorsea against the leafminer Liriomyza bryoniae (Kaltenbach,) [Diptera: Agromyzidae] was assessed. The oxymatrine was achieved 83.3% and 78.6% mortality of larvae and pupae at half field doses respectively. The mortality rate of larvae by Beauveria bassiana was 55.6 %, at a concentration of 107 spores/ml, and the LC50 value was 8.4 x104 spores/ml. larvae mortality by Isaria fumosorsea was 52% at a concentration of 107 spores/ml with LC50 value of 2.6 105 spores/ml. The mortality rate of pupae was 54.3% and 42.3%by by Beauveria bassiana and Isaria fumosorsea respectively at 107 spores/ml concentration. There was an increase in the mortality rate due to the combined action of the Beauveria bassiana and the oxymatrine ( 88%) it does exceed synergistic effect ( chi square= 4.92), and71.3% by the combination of the oxymatrine and Isaria fumosorosea synergistic effect (chi square= 4.65). In the case of pupae treatment, an increase in the rate of mortality was achieved, but it did not express synergism.