Abstract : Introduction: Breast cancer is the most frequent malignancy among females worldwide, and is associated with severe mental and emotional outcomes than other cancer. One of the psychological consequences of breast cancer is depression. The prevalence of depression is influenced by multiple factors, one of which was the level of social support. Women with high levels of support experience better psychosocial adjustment, and less depression during and after treatment for breast cancer. Objectives: Assessment the level of depression and social support among breast cancer women, and determine the association of depression with social support and socio-demographic characteristics. Patients and Method: A cross-sectional study was done involving 250 women with breast cancer who attended the oncology clinics of Imam Hussein and Imam Al-Hassan Al-Mujtaba teaching hospital in Karbala, Iraq from 1st March to 30th June. Data were collected by direct interview using a structured questionnaire, PHQ-9 to assess the level of depression, and MSPSS to assess the patient’s social support and were analyzed using SPSS version 24, and p value considered statistically significant when it is 0.05. Results: The prevalence of depression was (36.8%). About (54%) of breast cancer women had high total social support. The level of depression and social support were significantly associated with the marital status, the number of children, living status, and monthly income P 0.05. Also, the result showed that the level of depression decreases significantly with the increase in the level of social support in breast cancer women. Conclusions: There was a high prevalence of depression among breast cancer women. It decreases significantly with the increase in social support for them. Integration of screening programs for depression and psychosocial service provision in routine cancer care is recommended, and a support system for coordinating various types of support from the family, their healthcare professionals and community organizations in a way of teamwork to activate their social support systems, and working collaboratively as a multidisciplinary team to support patients financially and psychologically.