Abstract : Introduction: Type II Diabetes mellitus (DM) is related to the insulin hormone and is seen when this hormone is incomplete or inadequate. Type II DM is a chronic disease characterized by hyperglycemia, and its incidence and serious complications have increased in recent years. Neutrophil to Lymphocyte Ratio (NLR) and Platelet-lymphocyte ratio (PLR) are important markers used in the diagnosis of general inflammatory conditions in the human body. It is stated that NLR and PLR are cheap and easily calculable markers that correlate with the prognosis of systemic inflammatory diseases and are frequently used in laboratories. Material and Methods: This is an analytic observational and cross-sectional study with a approach to determine the difference of NLR and LMR values in patients with type 2 diabetes mellitus control and uncontrolled groups attending at Tertiary care Teaching Hospital over a period of 2 year. Laboratory examination data were taken from the Laboratory Information System (LIS), while patient demographic data, medical history, duration of illness, and drugs consumed were taken from medical record data. Furthermore, the NLR and LMR values were recorded for the NLR value obtained from the absolute neutrophils divided with absolute lymphocytes. In contrast, the LMR value was obtained from absolute lymphocytes divided by absolute monocytes. Result: The study was carried out on 100 diabetics and 100 subjects were used as controls. The mean age in the diabetics was 51.3 ± 3.6 years and in controls, it was 61.57 ± 5.73 years. The mean Systolic Blood Pressure (mm of Hg) in the diabetics was 131.5 ± 12.7 and, in controls, it was 115.6 ± 4.98. The mean Diastolic Blood Pressure (mm of Hg) in the diabetics was 90.6 ± 12.6 and, in controls, it was 77.0 ± 4.8. The mean fasting blood glucose in the diabetics was 159.53 ± 11.83 mg/dL and, in controls, it was 86.93 ± 5.39 mg/dL. The mean Postprandial blood glucose in the diabetics was 213.1 ± 20.9 mg/dL and, in controls, it was 130.76 ± 4.51 mg/dL. The mean HbA1c was 7.69 ± 0.61% in the diabetics and 4.97 ± 0.25% in controls. The mean Platelets was 239.42 ± 69.84 in the diabetics and 4.97 ± 0.25% in controls. The mean NLR was 2.5 and 1.02 in the cases and controls, respectively. The mean PLR was 119.7 and 95.2 in the cases and controls, respectively. Conclusion: Neutrophil to lymphocyte ratio (NLR) in the uncontrolled type 2 DM group was significantly higher than in the controlled type 2 DM group. Meanwhile, the lymphocyte to monocyte ratio (LMR) did not significantly differ between the two groups. Further research that did not use secondary data is expected so the patient’s body mass index, lipid profile, length of diabetes, and type of therapy can be evaluated. Keywords: Type II Diabetes mellitus, Neutrophil to Lymphocyte (NLR), Platelet-lymphocyte ratio (PLR)