Abstract : Breast carcinoma is the second most common cancer following lung cancer, The invasive ductal carcinoma is the most common type of breast cancer. About 8 in 10 invasive breast cancers are invasive (or infiltrating) ductal carcinomas (IDC). IDC begins in the breast milk duct's lining cells. The malignancy then spreads to the adjacent breast tissues after penetrating the duct's wall. At this point, it may be able to spread (metastasize) to other parts of the body through the lymph system and bloodstream.Sixty samples were taken from Al Karama Teaching Hospital and private Laboratory in Kut /wasit during the period from (October 1 ,2021 to January 1,2022) totally (60) samples ,(40)samples cancer and (20) samples normal. For histopathological and immunohistochemistry analysis. The total patients were divided according to their age in to five groups ( 20-29),(30-39),(40-49),(50-59) and above 60.Reslts of present study revealed that a highest incidence of breast cancer ( 55%) occur in the age above 50 years ,there is a significant difference among patients groups (p0.001). Histopathologically results revealed that 27 cases (67.50%) of them were classified as grade II ductal carcinoma while the remaining (7)cases (17.5%) and (5)15% were grade I and grade II in the same order .The results of immunohistochemical analysis showed that calretinin showed 0(0%) of normal were positive ,but 17(42.5%) of invasive ductal carcinoma were positive ,while 20(100%) of normal were negative and 23(57.5%) were negative.